The Spinellis are first mentioned in Parents' Night when it is discover that Spinelli has been lying to the school and the students for years that her parents were always being busy on the schools parents' night. Her excuses, according to the group get more and more far fetched every year.
At one point Ashley Spinelli insists that her parents are secret agents in an attempt to keep her friends from asking questions. At the end of the episode it is revealed that her father is at least a secret agent. Flo and Bob are both guilty of embarrassing their youngest child and only daughter; however they do not seem to feel ashamed about this at all, and practically make a habit out of it. This is proven in the episode "Parents' Night"; the episode of their debut.
- Main Article: Ashley Spinelli
- Main article: Flo Spinelli
Joey Spinelli is Ashley Spinelli's unseen older 17 year old brother in the series.
Little is known about Joey; but according to Spinelli in "Operation Field Trip",he majored in auto repair in prison for his job. Though in an earlier episode "First Name Ashley"; he was living at home at the time or at least just visiting there, Spinelli said that he once told her about a guy who was chopped up at a museum.
- In the show's Italian dub, his name is changed to Tony.
- The boots Spinelli wears were hand-me-downs from Joey.
Gordy is one of Spinelli's cousins. Not much is known about him, except that he taught her how to open a door with a Hairpin
Flo's mother (Spinelli's grandmother) Angie is apparently very good friends with Muriel Finster, there is an old photograph of Mrs. Finster and Spinelli's Grandmother taken back in the year 1952 kept in Finster's Bedroom.
Not much is known about him. Flo's father (Spinelli's grandfather) Dave was a navy seal, but used to embarrass Flo to the point of she lying about him (Similar to Spinelli).
Not much is known about Spinelli's Great-Aunt Ashley. She was a family hero and is Spinelli's namesake.