Spiro T. Agnew Middle School is a middle school located in the Unnamed City; it is where students from Third Street School go after they finish the Sixth Grade. It is named for Spiro T. Agnew, the first Vice President under President Richard Nixon and a governor of Maryland. It was first mentioned in the episode "The Great Jungle Gym Standoff".

Principal Peter Prickly attempts to impress the school district's superintendent at various points throughout the series in an attempt to secure the job of principal there. Despite coming very close in the episode "Prickly is Leaving", he ultimately turned down the job, under the pretense that Skinner didn't give him a better pay offer. In another Disney series called Shorty McShorts' Shorts, one short feature a school called Spiro Agnew Junior High, probably a reference to Recess.